In this recent paper, the P4SB consortium discusses the state of the art in plastic recycling through synthetic biology, and proposes a novel approach using Pseudomonas putida as a chassis for a novel, synthetic strain with enhanced capabilities.
Prof. Blank - coordinator of P4SB - is attending the iGEM 2015 Giant Jamboree (http://2015.igem.org/Giant_Jamboree). The Giant Jamboree is the annual event where all of the collegiate and high school iGEM teams come together to present their synthetic biology projects. This year more than 260 international, multidisciplinary teams are eager to share and celebrate their work.
The iGEM competition encourages university and high school student researchers to work in teams and solve real-world challenges by building genetically engineered biological systems with standard, interchangeable parts called BioBricks from the Registry of Standard Biological Parts. Each team manages their own projects, advocates for their research, and secures funding. Teams are also challenged to actively consider and address the safety, security and environmental implications of their work.
Our project partners CSIC and University College Dublin are participating those days at the ESBP2015 - 8th European Symposium on Biopolymers (http://www.esbp2015.org/). Let´s keep our fingers crossed, that Auxiliadora Prieto from CSIC gets her chance to present P4SB during the discussion "filling the gap from research/innovation to the market” and on “lesson learning” examples of cooperative public/private cooperation in European projects. Go for it!
When preparing its policy and proposals relating to consumer safety, public health and environment, the European Commission relies on the independent non-food Scientific Committees to provide it with sound scientific advice. Their opinions are vital for policy makers to ensure the highest level of health and environmental protection that European citizens expect from the European Union.
Make a difference for Europe! Join us! The European Commission is currently looking for top scientists to join the non-food Scientific Committees for the term 2016-2021. Your scientific skills can make a difference for the lives of European citizens. If you would like to be considered for membership of these Scientific Committees, this call is for you! You can apply for membership of: • the Scientific Committee on Consumer Safety ( SCCS) • the Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Each Committee consists of a maximum of 19 members. The working language is English.
Manuel Salvador, Juhyun Kim, Jaime Gonzalez and Jose Jimenez University of Surrey, Surrey, UK
Polyethylene terephthalate (PET) and polyurethane (PU) are the main oil-derived plastics and are massively used in a wide variety of daily products. These compounds are nowadays recycled at a low rate, which poses a great environmental concern. We are part of the H2020 consortium P4SB: From Plastic Waste to Plastic Value using Pseudomonas putida Synthetic Biology that proposes a novel approach to tackle the problem of inefficient recycling. In this approach P. putida, which its versatile metabolism can sustain the biodegradation and biotransformation of aliphatic and aromatic compounds, will be adopted as a genomic and metabolic chassis. We will use it to express engineered PET and PU hydrolysing enzymes for the depolymerisation of these plastics into their monomeric components. These will be then funneled into central metabolites by the native pathways of the bacterium and next directed towards production of the bio-degradable bio-plastic polyhydroxalkanoate. This platform constitutes an example of consolidated bioprocessing where all the specifications of an industrial process will be programmed in just one single catalyst. However, performance of metabolic programmed strains is highly dependent on the correct allocation of cellular resources and for this reason we will focus in attenuating the interplay of synthetic circuits with the host optimizing the usage of transcriptional and translational resources.
Aim: To assess the expected impact, the potential uptake and exploitation, the potential benefits of clustering and good practises to maximize impact.
This is a good opportunity to provide a valuable contribution to the discussion on how to maximize the potential impact and relevance of these research and innovation projects and to explore the potential added value of possible clustering activities.